Projects
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Discovery of novel niche factors to improve long-term stem cell transplantation in bone marrow failure syndromes. 

2023- 2025 (Fellowship): Discovery of novel niche factors to improve long-term stem cell transplantation in bone marrow failure syndromes. Dr Vashe Chandrakanthan, The University of Adelaide.

For many patients with Bone Marrow Failure Syndromes, a bone marrow transplant is the only hope for a cure. However, for a transplant to be effective the transplanted stem cells need to mature, and develop into long-term healthy adult stem cells. If this doesn’t happen, the transplant could fail.

It’s vital that there are more treatment options to increase the number of marrow-stimulating molecules and improve outcomes for patients with severe marrow failure. Dr Chandrakanthan’s research looks at developing a growth factor based treatment to help the transplanted stem cells to mature and produce healthy blood. This research could potentially transform the transplantation management of patients with Bone Marrow Failure Syndromes.

Related Projects

Prevention and treatment of bone marrow failure in Fanconi anaemia and other inherited disorders. (Part 2)

2017-2019 (Grant): Part 2 – Prevention and treatment of bone marrow failure in Fanconi anaemia and other inherited disorders. Dr Wayne Crismani, St Vincent’s Institute of Medical Research. Dr Wayne Crismani from the St ...

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Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention.  

2018-2020 (Co-funded VCA/MRV International Travelling Fellowship): Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention. Dr Ashvind Prabahran, The Royal ...

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Dissecting immune dysregulation in acquired bone marrow failure syndromes to identify new therapeutic leads. 

2022-2024 (Fellowship): Dissecting immune dysregulation in acquired bone marrow failure syndromes to identify new therapeutic leads. Dr Rachel Koldej, ACRF Translational Research Laboratory, Melbourne Health.

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High resolution definition of the mechanisms of poor graft function following allogeneic haematopoietic stem cell transplantation

2023 – 2026 (Fellowship): New Investigator PhD Scholarship, co-funded with the Haematology Society of Australia and New Zealand. High resolution definition of the mechanisms of poor graft function following allogeneic haematopoietic stem cell ...

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