Projects
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Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for Aplastic Anaemia and other Bone Marrow Failure Syndromes. 

2017-2021 Flavorite Fellowship, Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for Aplastic Anaemia and other Bone Marrow Failure Syndromes, Dr Yih-Chih Chan, The University of Melbourne and Peter MacCallum Cancer Centre

Aplastic Anaemia occurs when the body stops producing enough new blood cells. In about half of Aplastic Anaemia patients, the genetic mutation appears to be in genes that influence expression (epigenetic regulators) not in the conventional gene-coding area itself. This fellowship supports the study of an important group of epigenetic regulator proteins (called polycomb complex) that can modify blood cell development by altering gene expression and activity. 

The studies in this fellowship have identified an epigenetic regulator expressed by haematopoietic stem cells that may be involved in stem cell regeneration. If these studies are correct, then using this knowledge to reverse stem cell exhaustion may help improve bone marrow failure symptoms.

Related Projects

Improving capability and capacity of nurses to assess and manage young people with symptoms associated with acquired and inherited bone marrow failure syndromes. 

2022-2024 (Fiona Riewoldt Nursing/Allied Health Fellowship): Improving capability and capacity of nurses to assess and manage young people with symptoms associated with acquired and inherited bone marrow failure syndromes. Rachel Edwards, ...

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Dissecting immune dysregulation in acquired bone marrow failure syndromes to identify new therapeutic leads. 

2022-2025 (Fellowship): Dissecting immune dysregulation in acquired Bone Marrow Failure Syndromes to identify new therapeutic leads. Associate Professor Rachel Koldej, ACRF Translational Research Laboratory, Melbourne Health. Bone Marrow Failure ...

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Utility of a neurobehavioural assessment for treatment planning, educational, and family support for children undergoing bone marrow transplant for non-malignant disease. 

2023-2025 (Fiona Riewoldt Nursing/Allied Health Fellowship): Utility of a neurobehavioural assessment for treatment planning, educational, and family support for children undergoing bone marrow transplant for non-malignant ...

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Improving outcomes for Australian patients and families with bone marrow failure related diseases through comprehensive clinicogenomic care and collaborative research.

2021-2024 (Fellowship): Improving outcomes for Australian patients and families with bone marrow failure related diseases through comprehensive clinicogenomic care and collaborative research. Dr Lucy Fox, Peter MacCallum Cancer Centre. Dr Lucy ...

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