Aplastic Anaemia occurs when the body stops producing enough new blood cells. In about half of Aplastic Anaemia patients, the genetic mutation appears to be in genes that influence expression (epigenetic regulators) not in the conventional gene-coding area itself. This fellowship supports the study of an important group of epigenetic regulator proteins (called polycomb complex) that can modify blood cell development by altering gene expression and activity.
The studies in this fellowship have identified an epigenetic regulator expressed by haematopoietic stem cells that may be involved in stem cell regeneration. If these studies are correct, then using this knowledge to reverse stem cell exhaustion may help improve bone marrow failure symptoms.
2018-2021 (Doctoral Degree Fellowship): Clinical, genomic and molecular determinants of outcome in patients with Bone Marrow Failure Syndromes, Dr Lucy Fox, The University of Melbourne. This project is the first scholarship in Australia to ...
Read more2019-2021 (Fellowship): The Alex Gadomski Fellowship. Functional interrogation of Loci associated with the regulation of haematopoiesis. Dr Kirsten Fairfax, Menzies Institute for Medical Research and University of Tasmania. To understand bone ...
Read more2022-2024 (Fiona Riewoldt Nursing/Allied Health Fellowship): Improving capability and capacity of nurses to assess and manage young people with symptoms associated with acquired and inherited bone marrow failure syndromes. Rachel Edwards, ...
Read more2021-2024 (Fellowship): Improving outcomes for Australian patients and families with bone marrow failure related diseases through comprehensive clinicogenomic care and collaborative research. Dr Lucy Fox, Peter MacCallum Cancer Centre. Dr Lucy ...
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