Projects
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Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention.  

2019-2023 (Co-funded VCA/Maddie Riewoldt’s Vision International Travelling Fellowship): Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention. Dr Ashvind Prabahran, Melbourne Health.

Aplastic Anaemia results from the immune system attacking the bone marrow spontaneously. Poor Graft Function (PGF) refers to a type of bone marrow failure that occurs after bone marrow transplantation when, despite the recipient’s bone marrow being filled with 100% donor cells, the donor bone marrow fails to function. PGF results in significant complications for patients after bone marrow transplant and further understanding of this condition is required. Aplastic Anaemia and PGF both result in low blood cell levels and there may be similarities between these two conditions. If we can confirm similarities with Aplastic Anaemia, this will allow the faster development of therapies in both PGF and Aplastic Anaemia, as patients with PGF and Aplastic Anaemia can be studied together in future clinical trials.

Related Projects

Discovery of novel niche factors to improve long-term stem cell transplantation in Bone Marrow Failure Syndromes. 

2023- 2025 (Fellowship): Discovery of novel niche factors to improve long-term stem cell transplantation in bone marrow failure syndromes. Dr Vashe Chandrakanthan, The University of Adelaide. For many patients with Bone Marrow Failure Syndromes, ...

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Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic Bone Marrow Failure Syndromes.

2020-2023 (Fellowship): Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic Bone Marrow Failure Syndromes. Dr Parvathy Venugopal, Centre for Cancer Biology / University of South Australia. In ...

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Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for Aplastic Anaemia and other Bone Marrow Failure Syndromes. 

2017-2021 Flavorite Fellowship, Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for Aplastic Anaemia and other Bone Marrow Failure Syndromes, Dr Yih-Chih Chan, The University of Melbourne and Peter ...

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Towards targeted treatments for Fanconi Anaemia 

2017 – 2019 Fellowship / 2017 Grant-in-Aid, Towards targeted treatments for Fanconi Anaemia, Associate Professor Wayne Crismani, St Vincents Institute for Medical Research Fanconi Anaemia is an inherited disorder which can lead to bone ...

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