Projects
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Functional interrogation of Loci associated with the regulation of haematopoiesis

2019-2021 (Fellowship): The Alex Gadomski Fellowship. Functional interrogation of Loci associated with the regulation of haematopoiesis. Dr Kirsten Fairfax, Menzies Institute for Medical Research and University of Tasmania.

To understand bone marrow failure and identify new treatments, detailed knowledge on how different types of blood cells are formed is essential. This work aimed to answer two fundamental questions: ‘What genes determine the proportion of specific cell types in the blood?’ and ‘What are the underlying genetic drivers for gene expression in different blood cells?’.

Over 1000 blood samples and 72 bone marrow samples from Tasmanians were subjected to in-depth analysis to gain a deeper understanding of how genetic differences between people affect the development of blood cells. Several publications have resulted from this work, helping to predict how genetic variants affect the severity of bone marrow failure and providing important information on potential new targets for treatment.

Related Projects

Towards targeted treatments for Fanconi Anaemia 

2017 – 2019 Fellowship / 2017 Grant-in-Aid, Towards targeted treatments for Fanconi Anaemia, Associate Professor Wayne Crismani, St Vincents Institute for Medical Research Fanconi Anaemia is an inherited disorder which can lead to bone ...

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Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic Bone Marrow Failure Syndromes.

2020-2023 (Fellowship): Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic Bone Marrow Failure Syndromes. Dr Parvathy Venugopal, Centre for Cancer Biology / University of South Australia. In ...

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A preclinical trial of next generation gene editing for the prevention of bone marrow failure in Fanconi Anaemia

2023- 2025 (Fellowship): The inaugural Captain Courageous Fellowship. A preclinical trial of next generation gene editing for the prevention of bone marrow failure in Fanconi Anaemia. Dr Astrid Glaser at the Genome Stability Unit of St Vincent’s ...

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Discovery of novel niche factors to improve long-term stem cell transplantation in Bone Marrow Failure Syndromes. 

2023- 2025 (Fellowship): Discovery of novel niche factors to improve long-term stem cell transplantation in bone marrow failure syndromes. Dr Vashe Chandrakanthan, The University of Adelaide. For many patients with Bone Marrow Failure Syndromes, ...

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