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Current Projects

CRE in Bone Marrow Biology Research Portfolio

Thanks to our incredible supporters, we are able to fund innovative and exceptional medical research towards finding new treatments and cures for Bone Marrow Failure Syndromes.

Through our Centre of Research Excellence in Bone Marrow Biology, we purposefully identify and support the brightest researchers in Australia and have committed over $7.8M to funding 29 research projects since 2015.  For current funding opportunities, please see our Grants Scheme page here.

 Please find below a list of completed and current research projects: 

  • 2015-2018: The Australian Aplastic Anaemia Registry as a Means for Advancing Effective Treatment of Aplastic Anaemia. Monash University, on behalf of the Aplastic Anaemia Registry (AAR) - an initiative of the Transfusion Outcomes Research Collaborative (a consortium of members of the  Monash University Department of Epidemiology and Preventive Medicine at The Alfred Hospital, along with members of the Red Cross Blood Service). The registry received ongoing support in 2018 (see below) and has been re-named The Australian Aplastic Anaemia and other Bone Marrow Failure Syndromes Registry. Read more about the project here and for further information, please visit the Registry's website.
  • 2016-2019 (Fellowship): Part 1 - Prevention and treatment of bone marrow failure in Fanconi anaemia and other inherited disorders. Dr Wayne Crismani, St Vincent's Institute of Medical Research. 
  • 2017-2019 (Grant): Part 2 - Prevention and treatment of bone marrow failure in Fanconi anaemia and other inherited disorders. Dr Wayne Crismani, St Vincent's Institute of Medical Research. Read about Part 1 and Part 2 of Dr Crismani's project here.
  • 2016-2018 (Grant): Identification of miRNA biomarkers which play a functional role in disease pathogenesis and are predictive of inferior outcomes in AA/MDS. Dr Lynette Chee, The Royal Melbourne Hospital/Melbourne Health. Read more about the project here.
  • 2017-2020 (Fellowship): Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for aplastic anaemia and other bone marrow failure syndromes. Dr Yih-Chih Chan and Professor Mark Dawson, The University of Melbourne through the Sir Peter MacCallum Department of Oncology. Read more about the project here.
  • 2017-2019 (Grant): Predicting malignant transformation of bone marrow failure syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA). Dr Piers Blombery, Peter MacCallum Cancer Centre. Read more about the project here.
  • 2018-2020 (Grant): Influences of clonal haematopoiesis in allogeneic bone marrow transplantation. Dr Paul Yeh and Professor Mark Dawson, The University of Melbourne. Read more about the project here.
  • 2019-2020 (Doctoral Degree Fellowship): Bone Marrow Failure Syndromes in Australia: improving diagnosis to inform strategies for better care and outcomes. Dr Lucy Fox, The University of Melbourne. Read more about the project here.
  • 2018-2020 (Grant): Identifying therapeutics which can be repurposed for the treatment of Myelodysplastic Syndromes and other Bone Marrow Failure Disorders. Dr Amee George, The Australian National University. Read more about the project here.
  • 2018-2020 (Grant): Using induced pluripotent stem cells to find causes and cures for bone marrow failure in children and young adults. Professor Andrew Elefanty, Murdoch Children's Research Institute. Read more about the project here.
  • 2018-2020 (Grant): Discovering new genes and mutations that cause failure of bone marrow neutrophil production. Professor Graham Lieschke, Australian Regenerative Medicine Institute/Monash University and The Royal Melbourne Hospital. Read more about the project here.
  • 2018-2020 (Co-funded VCA/MRV International Travelling Fellowship): Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention. Dr Ashvind Prabahran, The Royal Melbourne Hospital/Melbourne Health. Read more about this project here.
  • 2018-2020 (co-funded Snowdome/Gunn Family/Maddie Riewoldt's Vision) The Gunn Family National Fellowship for Career Development in Research - Women in Haematology. Novel blood biomarkers for predicting bone marrow failure in Myeloproliferative neoplasms. Dr Belinda Guo, University of Western Australia. Read more about this project here.
  • 2019-2021 (Fellowship): The Alex Gadomski Fellowship. Functional interrogation of Loci associated with the Regulation of Haematopoiesis. Dr Kirsten Fairfax, Menzies Institute for Medical Research and University of Tasmania. Read more about this project here.
  • 2019-2020 (Grant): Extension to The Australian Aplastic Anaemia and other Bone Marrow Failure Syndromes Registry (see above). Professor Erica Wood, Monash University Department of Epidemiology and Preventative Medicine. Read more about the project here and for further information, please visit the registry's website.
  • 2019-2021 (Grant): Evaluating Multidisciplinary Bone Marrow Failure Syndrome Care - a prospective observational clinical trial offering comprehensive diagnostic genomic evaluation, multidisciplinary case review and multidisciplinary clinical care. Dr Lucy Fox and Dr Piers Blombery, The University of Melbourne and Clinical Haematology, Peter MacCallum Cancer Centre and The Royal Melbourne Hospital. Read more about the project here.
  • 2020-2022 (Fellowship): Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic bone marrow failure syndromes. Dr Parvathy Venugopal, Centre for Cancer Biology / University of South Australia. Read more about the project here.
  • 2020-2021 (Grant-in-Aid): Establishing an in vivo humanised mouse model for telomere related bone marrow failure syndromes. Professor Tracy Bryan, Children's Medical Research Institute. Read more about the project here.
  • 2020-2021 (Grant-in-Aid): Microenvironmental determinants of Aplastic Anaemia progression to MDS / AML. Dr Rachel Koldej, ACRF Translational Research Laboratory, Melbourne Health. Read more about this project here.
  • 2020-2023 (Fellowship): The Alex Gadomski PhD Scholarship in Medical Research, co-funded with the University of Tasmania. Determining genetic and epigenetic drivers of gene expression changes in blood cells. Ariel Simpson, Menzies Institute for Medical Research.
  • 2020-2023 (Grant): The Australian Bone Marrow Failure Biobank. Professor Melissa Southey, Biobanking Victoria, Monash University.
  • 2020-2023 (Program): The RESELECT Trial - REscuing bone marrow function in patients with relapsed aplaStic anaEmia and/or bone marrow failure post aLlogeneic stEm Cell Transplantation. PI - Professor David Ritchie.
  • 2020-2022 (GIA): Using whole genome sequence analysis to find answers for unsolved cases of inherited bone marrow failure syndrome. Dr Piers Blombery, The University of Melbourne.
  • 2020-2021 (GIA): Curation of the DIAAMOND-based Aplastic Anaemia Biobank. Associate Professor Stephen Ting, Monash University.
  • 2021-2023 (Fellowship): Improving outcomes for Australian patients and families with bone marrow failure related diseases through comprehensive clinicogenomic care and collaborative research. Dr Lucy Fox, Peter MacCallum Cancer Centre.
  • 2021-2023 (Fellowship): Determining genetic and epigenetic drivers of gene expression changes in blood cells. Dr Kirsten Fairfax, Menzies Institute for Medical Research and University of Tasmania. 
  • 2021-2023 (GIA): Studying a new gene editing technology (Prime Editing), with the aim of efficiently correcting Fanconi mutations. Dr Lorna McLeman, St Vincent's Institute of Medical Research. 
Collaborative Research Institutions
                             


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