Curation of the DIAAMOND-based Aplastic Anaemia Biobank

2021-2023 (Grant-in-Aid): Curation of the DIAAMOND-based Aplastic Anaemia Biobank. Associate Professor Stephen Ting, Monash University.

This project (the DIAAMOND biobank) is a sub-study of the DIAAMOND clinical trial and will collect, process and store patient blood and bone marrow samples from patients involved in DIAAMOND so they can be stored for future studies of the causes, diagnosis and treatment of Bone Marrow Failure Syndromes.

These samples will be eventually bio-banked with the Maddie’s Vision Australian Marrow Failure Biobank (AMFB) once the AMFB is operational. The DIAAMOND-Ava clinical trial (Diagnosis of Aplastic Anaemia, Management and Outcomes utilising a National Dataset) is a clinical trial testing a new stem cell stimulating drug, avatrombopag, in Aplastic Anaemia patients who have not received prior treatment and patients with relapsed or treatment unresponsive Aplastic Anaemia.

All trial participants are enrolled in the Aplastic Anaemia Registry which provides a framework for long term follow-up of these patients. Collecting patient samples from clinical trials such as DIAAMOND is critical for further understanding how diseases work and also why the trial treatment worked or did not work.