Projects
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Curation of the DIAAMOND-based Aplastic Anaemia Biobank

2021-2023 (Grant-in-Aid): Curation of the DIAAMOND-based Aplastic Anaemia Biobank. Associate Professor Stephen Ting, Monash University.

This project (the DIAAMOND biobank) is a sub-study of the DIAAMOND clinical trial and will collect, process and store patient blood and bone marrow samples from patients involved in DIAAMOND so they can be stored for future studies of the causes, diagnosis and treatment of Bone Marrow Failure Syndromes.

These samples will be eventually bio-banked with the Maddie’s Vision Australian Marrow Failure Biobank (AMFB) once the AMFB is operational. The DIAAMOND-Ava clinical trial (Diagnosis of Aplastic Anaemia, Management and Outcomes utilising a National Dataset) is a clinical trial testing a new stem cell stimulating drug, avatrombopag, in Aplastic Anaemia patients who have not received prior treatment and patients with relapsed or treatment unresponsive Aplastic Anaemia.

All trial participants are enrolled in the Aplastic Anaemia Registry which provides a framework for long term follow-up of these patients. Collecting patient samples from clinical trials such as DIAAMOND is critical for further understanding how diseases work and also why the trial treatment worked or did not work.

Related Projects

Towards targeted treatments for Fanconi Anaemia 

2017 – 2019 Fellowship / 2017 Grant-in-Aid, Towards targeted treatments for Fanconi Anaemia, Associate Professor Wayne Crismani, St Vincents Institute for Medical Research Fanconi Anaemia is an inherited disorder which can lead to bone ...

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Discovering new genes and mutations that cause failure of bone marrow neutrophil production. 

2018-2020 (Grant in aid): Discovering new genes and mutations that cause failure of bone marrow neutrophil production. Professor Graham Lieschke, Australian Regenerative Medicine Institute/Monash University and The Royal Melbourne Hospital. ...

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Predicting malignant transformation of Bone Marrow Failure Syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA).

2018-2020 (Grant-in-Aid): Predicting malignant transformation of Bone Marrow Failure Syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA). Associate Professor Piers Blombery, Peter MacCallum Cancer ...

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Using whole genome sequence analysis to find answers for unsolved cases of inherited Bone Marrow Failure Syndrome (iBMFS).

2020-2022 (Grant-in-Aid): Using whole genome sequence analysis to find answers for unsolved cases of inherited Bone marrow Failure Syndrome. Associate Professor Piers Blombery, The University of Melbourne. Inherited Bone Marrow Failure Syndromes ...

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