Projects
decoration

The RESELECT Trial – REscuing bone marrow function in patients with relapsed aplaStic anaEmia and/or bone marrow failure post aLlogeneic stEm Cell Transplantation

2020-2024 (Grant): Rescuing bone marrow function in relapsed acquired Aplastic Anaemia and /or poor graft function post allogeneic bone marrow transplantation, Professor David Ritchie, Melbourne Health.

Clinical trials are important for the testing of new treatments in disease. Clinical trials also can be used to collect patient samples to understand why treatments work or why they do not work. The RESELECT trial will identify and apply novel drug and cellular therapies to benefit patients with the high-risk Bone Marrow Failure Syndrome of relapsed Aplastic Anaemia or bone marrow failure after transplantation (Poor Graft Function – PGF). An initial trial of N-acetylcysteine and atorvastatin has been undertaken with 11 patients enrolled to date and samples collected from all patients. The trial continues to accrue at the anticipated rate, remains of high scientific value and is an important platform for international collaboration. Analysis of the samples will proceed once accrual has been fulfilled.

Related Projects

The Australian Bone Marrow Failure Biobank

2020-2025 (Grant): The Australian Bone Marrow Failure Biobank. Professor Melissa Southey, Biobanking Victoria, Monash University. The establishment of the Australian Marrow Failure Biobank, led by Maddie Riewoldt’s Vision, is a collaboration ...

Read more

Evaluating Multidisciplinary Bone Marrow Failure Syndrome Care – a prospective observational clinical trial offering comprehensive diagnostic genomic evaluation, multidisciplinary case review and multidisciplinary clinical care

2020-2023 (Grant): Evaluating Multidisciplinary Bone Marrow Failure Syndrome Care – a prospective observational clinical trial offering comprehensive diagnostic genomic evaluation, multidisciplinary case review and multidisciplinary clinical ...

Read more

A preclinical trial of next generation gene editing for the prevention of bone marrow failure in Fanconi Anaemia

2023- 2025 (Fellowship): The inaugural Captain Courageous Fellowship. A preclinical trial of next generation gene editing for the prevention of bone marrow failure in Fanconi Anaemia. Dr Astrid Glaser at the Genome Stability Unit of St Vincent’s ...

Read more

Predicting malignant transformation of Bone Marrow Failure Syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA).

2018-2020 (Grant-in-Aid): Predicting malignant transformation of Bone Marrow Failure Syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA). Associate Professor Piers Blombery, Peter MacCallum Cancer ...

Read more

Sign up to be the first to hear about our upcoming News & Events