To understand bone marrow failure and identify new treatments, detailed knowledge on how different types of blood cells are formed is essential. This work aimed to answer two fundamental questions: ‘What genes determine the proportion of specific cell types in the blood?’ and ‘What are the underlying genetic drivers for gene expression in different blood cells?’.
Over 1000 blood samples and 72 bone marrow samples from Tasmanians were subjected to in-depth analysis to gain a deeper understanding of how genetic differences between people affect the development of blood cells. Several publications have resulted from this work, helping to predict how genetic variants affect the severity of bone marrow failure and providing important information on potential new targets for treatment.
2023-2025 (Fiona Riewoldt Nursing/Allied Health Fellowship): Utility of a neurobehavioural assessment for treatment planning, educational, and family support for children undergoing bone marrow transplant for non-malignant ...
Read more2019-2023 (co-funded Snowdome/Gunn Family/Maddie Riewoldt’s Vision) The Gunn Family National Fellowship for Career Development in Research – Women in Haematology. Novel blood biomarkers for predicting bone marrow failure in Myeloproliferative ...
Read more2019-2023 (Co-funded VCA/Maddie Riewoldt’s Vision International Travelling Fellowship): Novel immunological assessment of Aplastic Anaemia and post transplant Graft Dysfunction for the purposes of targeted therapeutic intervention. Dr ...
Read more2020-2023 (Fellowship): Modelling consequences of cell abundance, heterogeneity and origin for autologous cell therapy in genetic Bone Marrow Failure Syndromes. Dr Parvathy Venugopal, Centre for Cancer Biology / University of South Australia. In ...
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