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MADDIE'S VISION

Maddie's Vision has a single focus: to fund the urgent needs in medical research that will discover improved treatments and a cure.

We need to understand more about Bone Marrow Failure Syndromes (BMFS). Current therapies are not well tolerated and today's BMFS patients and their families face a narrow range of treatment options that are very disruptive to daily life.

It is simply not acceptable to not have options for young BMFS patients. 

To achieve better outcomes, and to find a cure for BMFS, we are working with our highly reputable Grants Committee to develop a National Research Strategy. Their aim is to fund the research projects and people who we believe will find the breakthroughs this area of medicine so urgently needs. In just two years Maddie's Vision has raised $2.1M and as at June 2017 $1.085M has already been committed to funding a range of projects in partnership with medial research institutes across Australia. Each year, we will look for and continue to support the projects we believe will lead to breakthroughs.

our current projects

2015 – 2018: The Australian Aplastic Anaemia Registry as a Means for Advancing Effective Treatment of Aplastic Anaemia (Transfusion Outcomes Research Collaborative (TORC). TORC is a consortium of members at Monash University Department of Epidemiology and Preventive Medicine at The Alfred Hospital, along with members of the Red Cross Blood Service)

2016 – 2019: Prevention and treatment of bone marrow failure in Fanconi Anaemia and other inherited disorders – part 1 (Dr Wayne Crismani, St Vincent’s Research Institute)

20162018: Identification of miRNA biomarkers which play a functional role in disease pathogenesis and are predictive of inferior outcomes in AA/MDS (Dr Lynette Chee, Royal Melbourne Hospital)

20172020: Genome editing of haematopoietic stem and progenitor cells to uncover novel therapeutics for Aplastic Anaemia and other Bone Marrow Failure Syndromes (Dr Yih-Chih Chan and Prof Mark Dawson, Sir Peter MacCallum Cancer Centre)

20172019: Predicting malignant transformation of Bone Marrow Failure Syndromes using longitudinal targeted sequencing of peripheral blood and cell-free DNA (cfDNA) (Dr Piers Blombery, Victorian Comprehensive Cancer Centre)

20172019: Prevention and treatment of Bone Marrow Failure in Fanconi Anaemia and other inherited disorders – part 2 (Dr Wayne Crismani, St Vincents Research Institute)

20182020: Influences of clonal haematopoiesis in allogeneic bone marrow transplantation; co-funded with Snowdome Foundation (Prof Mark Dawson/Dr Paul Yeh, Sir Peter MacCallum Cancer Centre/Royal Melbourne Hospital)

OUR FUTURE 

With these cutting edge research projects underway we are now fundraising for two major, nationally and globally significant, projects: 

  1. The establishment of a world first National Bone Marrow Biobank. The purpose is to create the only national biobank in the world that will collect all tissues, blood and genetic material to store and analyse. This project will require a commitment of $250K/year for 3 years and we are well on our way with $100K already committed.
  2. The establishment of the world first  Centre of Excellence in Bone Marrow Biology. This goal involves developing systems and collaborating with experts across Australian centres to bring together a National Centre of Excellence, a ‘brains trust’ in Bone Marrow Biology. This is key to the foundations of a deeper understanding of Bone Marrow functioning and will require a commitment of $3M to establish and run over 5 years.

OUR COMMITMENT

Throughout everything we do, we are committed to:

- cutting edge medical research

- the development of collaborative, accessible information systems

- fixed term financial support for young researchers through Fellowship positions and Grant in Aid support

- national collaboration via diagnosis registry, establishment of a biobank to collect and store tissue samples

- the establishment of a central hub to coordinate research excellence in Bone Marrow biology